绿帽换妻

What we do

What is a complex intervention? It is "any deliberate initiated attempt to introduce new, or modify existing patterns, of collective action in healthcare or formal organisational setting intended to lead to changed outcomes" (1)

Our work in Complex Interventions involves the design, conduct, analysis and dissemination of large, multi-centre, pragmatic, phase III, randomised, controlled trials, evaluating complex health and social care interventions across a wide range of clinical specialities and settings, including stroke, older people, mental health, diet & obesity, cancer & palliative care, secondary, primary & community care and across transitions of care.

Interventions under evaluation comprise multiple interacting components, underpinned by theory-driven processes, such as rehabilitation, self-management, psychological, behavioural, supportive or lifestyle interventions, as well as complex drug regimens.  Interventions target individual, or groups of, patients, care-givers, health / care professionals or organisations.

Our portfolio also includes early-phase research, such as pilots, feasibility studies and intervention development; epidemiological studies and evidence synthesis; together with an active programme of methodological research investigating a broad range of real-world issues encountered during the design, implementation or analysis of complex intervention evaluations.

Major methodological research themes include:

• Clustering and multi-level structures.
• Design and analysis of early phase complex intervention studies.
• Development and appraisal of outcomes and measurement tools.
• Use of routine data in the design, implementation and analysis of clinical trials.
• Design of process evaluations, including methods for maximising, measuring and monitoring intervention fidelity.

Our innovative, pragmatic trials compare complex interventions, to standard NHS or social care, by assessing effectiveness across multiple, patient-focussed outcomes, including symptom reduction, improvements in physical and mental health, activities of daily living, quality of life and other patient-reported outcomes, and cost effectiveness.

We answer questions, which are key to our stakeholders, including investigators, patients, healthcare providers, policy makers and the NHS. Our trials provide evidence which change clinical practice in the United Kingdom, Europe and world-wide.

References

1. .
   May C, Finch T, Mair F, Ballini L, Dowrick C, Eccles M, Gask L, MacFarlane A, Murray E, Rapley T, Rogers A, Treweek S, Wallace P, Anderson G, Burns J, Heaven B.
   BMC Health Serv Res. 2007 Sep 19;7:148.

Our trials

Funding

• National Institute for Health and Care Research
• Yorkshire Cancer Research
• Macmillan Cancer Support
• National Institues of Health
• Medical Research Council
• Chartered Society for Physiotherapy
• Wellcome Trust

Key publications

 

Who we are

Division Director
Professor Amanda Farrin

View our team

Contact us

General enquiries
Email: ctru_cid@leeds.ac.uk