LICAMM Our Research

绿帽换妻 Institute of Data Analytics (LIDA)

The home of data science at the 绿帽换妻

PGR Projects

We combine our research based curriculum with a range of opportunities to give you the knowledge, skills and experience to prepare for your future

Child Health Outcomes Research at 绿帽换妻 (CHORAL)

Improving the health and wellbeing of children and young people

绿帽换妻 Pregnancy Research Group

Improving the health of pregnant women and their children across the life course

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PGR Projects
CHORAL
Pregnancy Group

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LICAMM Our Research

Our Research

We work to understand and treat cardio metabolic diseases, a number of cardiac and circulatory disorders, linked to comorbidities such as diabetes or obesity. We view cardiometabolic disease as whole body and whole life problems that adversely affect wellbeing, societal contribution and life expectancy. We particularly focus our research on understanding the pathobiology of cardiovascular disease and how this is exacerbated by the comorbidity of type 2 diabetes. This deadly combination can reduce life expectancy by up to 15 years and is highly prevalent in the north of England. Our integrated teams of fundamental, data and clinical scientists work across university and hospital settings with the aim of helping people with, or at risk of, cardio metabolic disease. We work in partnership with patient and public involvement and engagement (PPIE) groups to ensure what we do is relevant to the community we serve.

What we do

We are interested in how disturbances in physical and metabolic homeostasis lead to related disorders including atherothrombosis, heart failure and vascular disease. We are further interested in how these disorders are phenotypically distinct where they have the added burden of diabetes. We hope that, informed by new knowledge, we can develop and implement new treatments and diagnostics.

We approach the heart, blood vessels, blood and metabolic organs as interacting components of a complex integrated body system that is shaped in its structure and function by metabolic events throughout life, from the embryo to old age. Our work encompasses the spectrum of scale from molecular and cellular studies of cardiovascular biology, organ and systems biology, animal models of disease, through to diagnosis and interventional trials.